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Clinical trials in the Cleveland area

746 studies are recruiting volunteers at 340 research sites in the Cleveland, OH area.

Sites in Cleveland, Beachwood, Westlake, Mentor, Independence, Avon and 22 more towns.

#36 in the US for recruiting studies#3 in Ohio#50 in the US per resident

Studies recruiting
746
Research sites
340
Conditions studied
149
Studies per 100,000 residents
34.3

Conditions being studied

The conditions with the most studies recruiting in the area. A study can be for more than one condition.

  • Lung cancer49 studies
  • Leukemia32 studies
  • Breast cancer31 studies
  • Liver disease31 studies
  • Inflammatory bowel disease (IBD)28 studies
  • Prostate cancer28 studies
  • Non-Hodgkin's lymphoma26 studies
  • Colorectal cancer (bowel cancer)22 studies
  • Head and neck cancer17 studies
  • Ovarian cancer17 studies
  • Uterine cancer17 studies
  • Crohn's disease16 studies
  • Depressive disorder15 studies
  • Kidney cancer15 studies
  • Psoriasis15 studies
All 149 conditions
  • Lung cancer49
  • Leukemia32
  • Breast cancer31
  • Liver disease31
  • Inflammatory bowel disease (IBD)28
  • Prostate cancer28
  • Non-Hodgkin's lymphoma26
  • Colorectal cancer (bowel cancer)22
  • Head and neck cancer17
  • Ovarian cancer17
  • Uterine cancer17
  • Crohn's disease16
  • Depressive disorder15
  • Kidney cancer15
  • Psoriasis15
  • Ulcerative colitis (UC)15
  • Bladder cancer14
  • Neuroendocrine tumor14
  • Fatty liver disease (MASH/NASH)13
  • Liver cancer13
  • Pancreatic cancer13
  • Endometrial cancer12
  • Esophageal cancer11
  • Heart failure11
  • Stroke11
  • Brain cancer10
  • Ischemic heart disease (IHD)10
  • Sarcoma of soft tissue10
  • Melanoma9
  • Parkinson's disease (PD)9
  • Peripheral nerve disease9
  • Skin cancer9
  • Systemic lupus erythematosus (SLE)9
  • Alzheimer's disease8
  • Peripheral vascular disease8
  • Anemia7
  • Cervical cancer7
  • Fallopian tube cancer7
  • Gastric cancer (stomach cancer)7
  • High blood pressure (hypertension)7
  • Myelodysplastic syndrome (MDS)7
  • Overweight and obesity7
  • Anxiety disorder6
  • Cardiovascular disease6
  • Interstitial lung disease6
  • Psoriatic arthritis (PsA)6
  • Schizophrenia6
  • Type 2 diabetes6
  • Age-related macular degeneration (AMD)5
  • Bipolar disorder5
  • Cystic fibrosis5
  • Intellectual disability5
  • Multiple myeloma (MM)5
  • Post-traumatic stress disorder (PTSD)5
  • Psychotic disorder5
  • Retinal degeneration5
  • Sickle cell disease5
  • Vasculitis5
  • Abdominal aortic aneurysm4
  • Asthma4
  • Biliary tract cancer4
  • Chronic obstructive pulmonary disease (COPD)4
  • COVID-194
  • Down syndrome4
  • Epilepsy4
  • Multiple sclerosis (MS)4
  • Traumatic brain injury4
  • Urinary incontinence4
  • Alcohol dependence3
  • Anal cancer3
  • Atrial fibrillation (AF)3
  • Autism spectrum disorder (ASD)3
  • Cardiomyopathy3
  • Chronic skin ulcer3
  • Congenital heart disease3
  • Eczema (atopic dermatitis)3
  • Hidradenitis suppurativa (HS)3
  • Hodgkin's lymphoma3
  • Influenza (flu)3
  • Juvenile idiopathic arthritis (JIA)3
  • Migraine3
  • Motor neuron disease (MND)3
  • Neuropathic pain3
  • Overactive bladder (OAB)3
  • Pulmonary hypertension3
  • Rheumatoid arthritis3
  • RSV infection3
  • Sleep apnea3
  • Thrombocytopenia3
  • Type 1 diabetes3
  • Abdominal cancer2
  • Acute coronary syndrome2
  • Alpha-1-antitrypsin deficiency (AATD)2
  • Amyotrophic lateral sclerosis (ALS)2
  • Diabetic eye disease2
  • Eating disorder2
  • Hearing loss2
  • Hemophilia A2
  • Hemophilia B2
  • Human immunodeficiency virus infection (HIV)2
  • Insomnia2
  • Myelofibrosis2
  • Neuroblastoma2
  • Palmoplantar pustulosis2
  • Post-transplant lymphoproliferative disorder2
  • Recurrent urinary tract infection (UTI)2
  • Rhabdomyosarcoma2
  • Scoliosis2
  • Thrombotic microangiopathy2
  • Tooth decay2
  • Alopecia1
  • Amyloidosis1
  • Axial spondyloarthritis1
  • Bile duct cancer1
  • Celiac disease1
  • Chloasma1
  • Chronic kidney disease (CKD)1
  • Complex regional pain syndrome (CRPS)1
  • Cutaneous T-cell lymphoma1
  • Dry eye syndrome1
  • Endometriosis1
  • Fabry's disease1
  • Familial multiple polyposis syndrome1
  • Frontotemporal dementia (FTD)1
  • Gallbladder cancer1
  • Gastrointestinal stromal tumor1
  • Germ cell tumor1
  • Glaucoma1
  • Hemolytic uremic syndrome1
  • Idiopathic inflammatory myopathy1
  • Immune thrombocytopenic purpura (ITP)1
  • Irritable bowel syndrome (IBS)1
  • Menopause symptoms1
  • Narcolepsy1
  • Ocular hypertension1
  • Opioid use disorder1
  • Peritoneal cancer1
  • Pompe disease1
  • Primary biliary cholangitis (PBC)1
  • Primary sclerosing cholangitis1
  • Progressive supranuclear palsy (PSP)1
  • Rotator cuff syndrome1
  • Schizoaffective disorder1
  • Short-sightedness (myopia)1
  • Spinal muscular atrophy (SMA)1
  • Systemic sclerosis1
  • Testicular cancer1
  • Tricuspid valve regurgitation1
  • Ureteral cancer1

206 more studies are for conditions not yet in our catalog.

Whom the studies accept

The share of the area's studies open to each group. A study can accept several.

  • Adults 18 to 6492%
  • Adults 65 and over83%
  • Children and teens (under 18)21%
  • Healthy volunteers8%
  • Open to all sexes92%
  • Women only5%
  • Men only3%

53 studies are for children only.

Study phases

Earlier phases test safety in fewer people; later phases compare a treatment with the usual care in many.

  • Early phase 11%
  • Phase 17%
  • Phase 1/25%
  • Phase 217%
  • Phase 2/34%
  • Phase 329%
  • Phase 44%
  • No phase (device, behavioral and other studies)22%
  • Not stated12%

Most active research sites

The sites recruiting for the most studies in the area.

  1. University Hospitals Cleveland Medical CenterCleveland223 studies
  2. Case Western Reserve UniversityCleveland81 studies
  3. MetroHealth Medical CenterCleveland44 studies
  4. Rainbow Babies and Childrens HospitalCleveland34 studies
  5. Cleveland Clinic Cancer Center/Fairview HospitalCleveland29 studies
  6. Hillcrest Hospital Cancer CenterCleveland29 studies
  7. UHHS-Chagrin Highlands Medical CenterBeachwood27 studies
  8. Louis Stokes VA Medical Center, Cleveland, OHCleveland23 studies
  9. UH Seidman Cancer Center at Lake Health Mentor CampusMentor22 studies
  10. UH Seidman Cancer Center at UH Avon Health CenterAvon18 studies
  11. Cleveland ClinicCleveland15 studies
  12. UH Cleveland Medical CenterCleveland15 studies
  13. University Hospitals, Seidman Cancer Center, Case Comprehensive Cancer CenterCleveland14 studies
  14. Great Lakes Gastroenterology Research, LLCMentor13 studies
  15. University HospitalsCleveland13 studies

Cite these figures

Free to use under CC BY 4.0. Please credit LocalTrial with a link to this page.

As text

Source: LocalTrial, Clinical trials in the Cleveland area, https://www.localtrial.com/clinical-trials/ohio/cleveland, updated November 12, 2026.

With the link, for a web page

Source: <a href="https://www.localtrial.com/clinical-trials/ohio/cleveland">LocalTrial, Clinical trials in the Cleveland area</a>, updated November 12, 2026.

About these figures

Counted from ClinicalTrials.gov, the U.S. registry of clinical studies, for studies recruiting in the United States. A study is counted once however many sites it has in the area.

The area is the U.S. Census Bureau's Cleveland, OH metropolitan area. Residents: 2,171,877, the Census Bureau's latest estimate. Updated November 12, 2026.

These figures describe studies, not advice. Talk to your doctor before joining one.

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