Clinical trials near you
Clinical trials in the Sioux Falls area
237 studies are recruiting volunteers at 74 research sites in the Sioux Falls, SD-MN area.
Sites in Sioux Falls.
#70 in the US for recruiting studies#1 in South Dakota#6 in the US per resident
- Studies recruiting
- 237
- Research sites
- 74
- Conditions studied
- 84
- Studies per 100,000 residents
- 76.9
Conditions being studied
The conditions with the most studies recruiting in the area. A study can be for more than one condition.
- Lung cancer32 studies
- Breast cancer23 studies
- Head and neck cancer18 studies
- Colorectal cancer (bowel cancer)17 studies
- Ovarian cancer17 studies
- Leukemia13 studies
- Uterine cancer13 studies
- Endometrial cancer11 studies
- Non-Hodgkin's lymphoma11 studies
- Prostate cancer10 studies
- Kidney cancer8 studies
- Heart failure7 studies
- Fallopian tube cancer6 studies
- Melanoma6 studies
- Neuroendocrine tumor6 studies
All 84 conditions
- Lung cancer32
- Breast cancer23
- Head and neck cancer18
- Colorectal cancer (bowel cancer)17
- Ovarian cancer17
- Leukemia13
- Uterine cancer13
- Endometrial cancer11
- Non-Hodgkin's lymphoma11
- Prostate cancer10
- Kidney cancer8
- Heart failure7
- Fallopian tube cancer6
- Melanoma6
- Neuroendocrine tumor6
- Pancreatic cancer6
- Retinal degeneration6
- Sarcoma of soft tissue6
- Skin cancer6
- Age-related macular degeneration (AMD)5
- Bladder cancer5
- Dry eye syndrome4
- Esophageal cancer4
- Gastric cancer (stomach cancer)4
- Inflammatory bowel disease (IBD)4
- Cardiovascular disease3
- Chronic obstructive pulmonary disease (COPD)3
- Intellectual disability3
- Macular edema3
- Neuroblastoma3
- Ulcerative colitis (UC)3
- Anemia2
- Cervical cancer2
- Crohn's disease2
- Depressive disorder2
- Down syndrome2
- Hodgkin's lymphoma2
- Interstitial lung disease2
- Liver disease2
- Multiple myeloma (MM)2
- Myelodysplastic syndrome (MDS)2
- Overactive bladder (OAB)2
- Overweight and obesity2
- Peripheral nerve disease2
- Short-sightedness (myopia)2
- Thrombocytopenia2
- Thrombotic microangiopathy2
- Urinary incontinence2
- Abdominal aortic aneurysm1
- Abdominal cancer1
- Anal cancer1
- Asthma1
- Ataxia-telangiectasia syndrome1
- Atrial fibrillation (AF)1
- Biliary tract cancer1
- Celiac disease1
- Chronic kidney disease (CKD)1
- Congenital heart disease1
- Diabetic eye disease1
- Friedreich ataxia1
- Frontotemporal dementia (FTD)1
- Gallbladder cancer1
- Germ cell tumor1
- Graft-versus-host disease1
- Hearing loss1
- Hemolytic uremic syndrome1
- High blood pressure (hypertension)1
- Immune thrombocytopenic purpura (ITP)1
- Migraine1
- Motor neuron disease (MND)1
- Narcolepsy1
- Opioid use disorder1
- Parkinson's disease (PD)1
- Peripheral vascular disease1
- Peritoneal cancer1
- Post-transplant lymphoproliferative disorder1
- Primary biliary cholangitis (PBC)1
- Rhabdomyosarcoma1
- Spinal muscular atrophy (SMA)1
- Systemic sclerosis1
- Type 1 diabetes1
- Type 2 diabetes1
- Vasculitis1
- Vulvar cancer1
38 more studies are for conditions not yet in our catalog.
Whom the studies accept
The share of the area's studies open to each group. A study can accept several.
- Adults 18 to 6496%
- Adults 65 and over85%
- Children and teens (under 18)17%
- Healthy volunteers5%
- Open to all sexes88%
- Women only10%
- Men only3%
8 studies are for children only.
Study phases
Earlier phases test safety in fewer people; later phases compare a treatment with the usual care in many.
- Phase 13%
- Phase 1/24%
- Phase 220%
- Phase 2/34%
- Phase 343%
- Phase 42%
- No phase (device, behavioral and other studies)10%
- Not stated13%
Most active research sites
The sites recruiting for the most studies in the area.
- Sanford USD Medical Center - Sioux FallsSioux Falls82 studies
- Sanford Cancer Center Oncology ClinicSioux Falls76 studies
- Avera Cancer InstituteSioux Falls48 studies
- Sanford HealthSioux Falls8 studies
- Sanford HealthSioux Falls8 studies
- Vance Thompson VisionSioux Falls8 studies
- Circle Clinical ResearchSioux Falls7 studies
- North Central HeartSioux Falls7 studies
- Avera Medical GroupSioux Falls6 studies
- Avera Research InstituteSioux Falls5 studies
- Ophthalmology Ltd.Sioux Falls5 studies
- Avera McKennan Hospital & University Health CenterSioux Falls3 studies
- Sanford USD Medical CenterSioux Falls3 studies
- Urology Specialists of South DakotaSioux Falls3 studies
- Sanford Children's Hospital-Sanford Children's Specialty ClinicSioux Falls2 studies
Cite these figures
Free to use under CC BY 4.0. Please credit LocalTrial with a link to this page.
Source: LocalTrial, Clinical trials in the Sioux Falls area, https://www.localtrial.com/clinical-trials/south-dakota/sioux-falls, updated November 12, 2026.
Source: <a href="https://www.localtrial.com/clinical-trials/south-dakota/sioux-falls">LocalTrial, Clinical trials in the Sioux Falls area</a>, updated November 12, 2026.
About these figures
Counted from ClinicalTrials.gov, the U.S. registry of clinical studies, for studies recruiting in the United States. A study is counted once however many sites it has in the area.
The area is the U.S. Census Bureau's Sioux Falls, SD-MN metropolitan area. Residents: 308,266, the Census Bureau's latest estimate. Updated November 12, 2026.
These figures describe studies, not advice. Talk to your doctor before joining one.
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